After a subdued opening, the benchmark faced sudden selling pressure in the last half-hour of trade to close at 39,452.07, down by 289.29 points, or 0.73 per cent.
On similar lines, the wider NSE Nifty tumbled 90.75 points, or 0.76 per cent, to finish at 11,823.30.
During the week, the Sensex fell 163.83 points or 0.41 per cent, while the Nifty lost 47.35 points or 0.39 per cent.
Top losers included IndusInd Bank, Bharti Airtel, Tata Motors, Axis Bank, Kotak Bank, Bajaj Auto, Yes Bank, HCL Tech, HUL and Hero MotoCorp, falling up to 4.36 per cent.
Barring capital goods, all BSE sectoral indices ended in the red.
On the global front, investors scurried to safe-haven assets after China’s industrial output growth in May sank to more than 17-year lows, highlighting risks to world growth.
Flaring up of geopolitical tensions in the Middle East following attacks on two oil tankers and continued uncertainty over US-China trade talks also weighed on risk sentiment.
“Ripple effect from a weak global market while premium valuation and slow economy are hurting the market. Continuous exchange of words between US and Tehran regarding the oil tanker attack, progress of US-China trade war, Fed policy outcome on 19th June and progress of monsoon will be closely watched by the investors. The market is cautious today awaiting these important events while highly leveraged companies are being mostly impacted,” said Vinod Nair, Head of Research, Geojit Financial Services.